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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về y học đề tài: The effects of IgM-enriched immunoglobulin preparations in patients with severe sepsis: another point of view. | Available online http ccforum.eom content 6 6 543 Letter The effects of IgM-enriched immunoglobulin preparations in patients with severe sepsis another point of view Stylianos Karatzas1 Eleni Boutzouka1 Kyriaki Venetsanou2 Pavlos Myrianthefs3 George Fildisis1 and George Baltopoulos4 Attending Physician Athens University School of Nursing ICU at KAT Hospital Greece 2Chemist Research Unit Athens University School of Nursing ICU at KAT Hospital Greece 3Research Fellow Northwestern University Department of Critical Care and Pulmonary Diseases Chicago Illinois USA 4Professor and Director of Athens University School of Nursing ICU at KAT Hospital Greece Correspondence Stylianos Karatzas stylkar@hotmail.com Published online 24 October 2002 Critical Care 2002 6 543-544 DOI 10.1186 cc1837 This article is online at http ccforum.com content 6 6 543 2002 BioMed Central Ltd Print ISSN 1364-8535 Online ISSN 1466-609X We read with interest the paper by Tugrul et al. 1 regarding the effects of IgM-enriched immunoglobulin preparations in patients with severe sepsis managed in their intensive care unit. Apart from the global interest of reading a paper in the field of the treatment of severe sepsis and septic shock we have an almost similar project in progress. It is well known that the immunotherapy in sepsis is still a gray zone and it will remain so as long as the relevant literature presents conflicting results 2 . From our understanding and the interim analysis of our data it seems that we could expect some definitive immunotherapy information in the near future. In our study we have presently included 34 patients in the treatment group IgM IgG IgA and 34 in the control group. Analyzing our data in a manner comparable with that of Tugrul et al. 1 we reach a different conclusion regarding the results. The only difference that exists between our protocol and that of Tugrul et al. regarding the study design and the inclusion criteria is that we include only adults older than 18 .
