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Báo cáo y học: " Inhibition or knock out of Inducible nitric oxide synthase result in resistance to bleomycin-induced lung injury"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:" Inhibition or knock out of Inducible nitric oxide synthase result in resistance to bleomycin-induced lung injury. | Respiratory Research BioMed Central Research Open Access Inhibition or knock out of Inducible nitric oxide synthase result in resistance to bleomycin-induced lung injury Tiziana Genovese 1 Salvatore Cuzzocrea 1 Rosanna Di Paola1 Marco Failla2 Emanuela Mazzon1 Maria Angela Sortino3 Giuseppina Frasca3 Elisa Gili2 Nunzio Crimi2 Achille P Caputi1 and Carlo Vancheri2 Address Department of Clinical and Experimental Medicine and Pharmacology Torre Biologica Policlinico Universitario 98123 Messina Italy 2Department of Internal and Specialistic Medicine Section of Respiratory Diseases University of Catania Catania Italy and 3Department of Experimental and Clinical Pharmacology University of Catania Catania Italy Email Tiziana Genovese - tgenovese@unime.it Salvatore Cuzzocrea - salvator@unime.it Rosanna Di Paola - dipaolar@unime.it Marco Failla - marcofailla@yahoo.it Emanuela Mazzon - ehazzon@unime.it Maria Angela Sortino - ccrisafulli@unime.it Giuseppina Frasca - rosanna103@interfree.it Elisa Gili - elisa@libero.it Nunzio Crimi - salvaor@imeuniv.unime.it Achille P Caputi - apcaputi@unime.it Carlo Vancheri - vancheri@unict.it Corresponding authors Published 14 June 2005 Received 17 February 2005 Respiratory Research 2005 6 58 doi l0.ll86 l465-992l-6-58 Accepted I4 June 2005 This article is available from http respiratory-research.cOm content 6 l 58 2005 Genovese et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background In the present study by comparing the responses in wild-type mice WT and mice lacking KO the inducible or type 2 nitric oxide synthase iNOS we investigated the role played by iNOS in the development of on the lung injury caused by bleomycin administration. When compared to bleomycin-treated iNOSWT mice