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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: Predominant constitutive CFTR conductance in small airways. | Respiratory Research BioMed Central Research Open Access Predominant constitutive CFTR conductance in small airways Xiaofei Wang1 Christian Lytle2 and Paul M Quinton 1 2 Address 1Dept. Pediatrics Medical School University of California San Diego San Diego CA USA and 2Dept. Biomedical Sciences University of California Riverside CA USA Email Xiaofei Wang - xfwang@ucsd.edu Christian Lytle - christian.lytle@ucr.edu Paul M Quinton - pquinton@ucsd.edu Corresponding author Published 17 January 2005 Received 02 November 2004 Respiratory Research 2005 6 7 doi l0.ll86 l465-992l-6-7 Accepted 17 January 2005 This article is available from http respiratory-research.cOm content 6 l 7 2005 Wang et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The pathological hallmarks of chronic obstructive pulmonary disease COPD are inflammation of the small airways bronchiolitis and destruction of lung parenchyma emphysema . These forms of disease arise from chronic prolonged infections which are usually never present in the normal lung. Despite the fact that primary hygiene and defense of the airways presumably requires a well controlled fluid environment on the surface of the bronchiolar airway very little is known of the fluid and electrolyte transport properties of airways of less than a few mm diameter. Methods We introduce a novel approach to examine some of these properties in a preparation of minimally traumatized porcine bronchioles of about l mm diameter by microperfusing the intact bronchiole. Results In bilateral isotonic NaCl Ringer solutions the spontaneous transepithelial potential TEP lumen to bath of the bronchiole was small mean sem -3 l mV n 25 but when gluconate replaced luminal Cl- the bionic Cl- diffusion
