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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:"Myosin heavy chain and physiological adaptation of the rat diaphragm in elastase-induced emphysema. | Respiratory Research BioMed Central Research Myosin heavy chain and physiological adaptation of the rat diaphragm in elastase-induced emphysema Dong Kwan Kim1 6 Jianliang Zhu1 Benjamin W Kozyak1 James M Burkman1 Neal A Rubinstein2 Edward B Lankford3 Hansell H Stedman1 2 4 Taitan Nguyen5 Sanford Levine2 5 and Joseph B Shrager 1 2 4 Open Access Address Department of Surgery University of Pennsylvania School of Medicine Philadelphia Pennsylvania USA Pennsylvania Muscle Institute University of Pennsylvania School of Medicine Philadelphia Pennsylvania USA 3Department of Pathology Anatomy and Cell Biology Thomas Jefferson University Philadelphia Pennsylvania USA 4Department of Surgery Philadelphia Veterans Affairs Medical Center Philadelphia Pennsylvania USA 5Department of Medicine Philadelphia Veterans Affairs Medical Center Philadelphia Pennsylvania USA and 6Present address Asan Medical Center University of Ulsan College of Medicine Seoul Korea Email Joseph B Shrager - jshrag@mail.ed.upenn.edu Corresponding author Published 17 February 2003 Received 27 July 2002 Accepted 1 November 2002 Respir Res 2003 4 1 This article is available from http www.respiratory-research content 4 1 1 2003 Kim et al licensee BioMed Central Ltd This article is published in Open Access verbatim copying and redistribution of this article are permitted in all media for any non-commercial purpose provided this notice is preserved along with the article s original URL. Abstract Background Several physiological adaptations occur in the respiratory muscles in rodent models of elastase-induced emphysema. Although the contractile properties of the diaphragm are altered in a way that suggests expression of slower isoforms of myosin heavy chain MHC it has been difficult to demonstrate a shift in MHCs in an animal model that corresponds to the shift toward slower MHCs seen in human emphysema. Methods We sought to identify MHC and corresponding physiological changes in the diaphragms of rats with .
