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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:Early glandular neoplasia of the lung. | http respiratory-research.eom content 1 3 163 Review Early glandular neoplasia of the lung William H Westra Department of Pathology The Johns Hopkins Medical Institutions Baltimore Maryland USA Received 20 October 2000 Revisions requested 9 November 2000 Revisions received 9 November 2000 Accepted 10 November 2000 Published 17 November 2000 Respir Res 2000 1 163-169 Current Science Ltd Print ISSN 1465-9921 Online ISSN 1465-993X Abstract Although bronchogenic carcinomas progress through a very well defined sequence of metaplasia dysplasia and carcinoma in situ very little is known about the early progression of glandular neoplasms of the lung. In particular the early precursor lesion from which fully malignant adenocarcinomas arise has effectively eluded recognition at least until recently. Several lines of evidence now implicate atypical adenomatous hyperplasia AAH as an initial morphologic stage in multistep lung tumorigenesis. Despite its small size AAH can be appreciated at the light microscopic level and characterized at the molecular genetic level. Indeed the genetic characterization of AAH promises to further our understanding of lung cancer development and might facilitate the design of novel strategies for early detection of lung cancer. Keywords adenocarcinoma atypical adenomatous hyperplasia atypical alveolar hyperplasia K-ras loss of heterozygosity lung cancer p53 telomerase Introduction Lung cancer is the leading cause of cancer death in the industrialized world 1 . A dismally low cure rate largely reflects the propensity of lung cancer to present as clinically advanced tumors most lung cancers are discovered late during their clinical course by which time the options for effective therapeutic intervention are limited. Of these lung cancers adenocarcinoma is now the most common subtype 2 . This subtype is particularly notorious for eluding early detection. Even vigilant screening of sputum samples for morphologic evidence of early glandular neoplasia in