Đang chuẩn bị nút TẢI XUỐNG, xin hãy chờ
Tải xuống
To evaluate the immune activation and reactive oxygen species scavenging activity of Cordyceps militaris polysaccharides (CMP) in vivo, 90 male BALB/c mice were randomly divided into six groups. The mice in the three experimental groups were given cyclophosphamide at 80 mg/kg/d via intraperitoneal injection and 17.5, 35, or 70 mg/kg body weight CMP via gavage. The lymphocyte proliferation, phagocytic index, and biochemical parameters were measured. The results show that the administration of CMP was able to overcome the CY-induced immunosuppression, significantly increased the spleen and thymus indices, and enhanced the spleen lymphocyte activity and macrophage function. CMP can also improve the antioxidation activity in immunosuppressed mice, significantly. | Carbohydrate Polymers 89 2012 461-466 Contents lists available at SciVerse ScienceDirect Carbohydrate Polymers journal homepage www.elsevier.com locate carbpol Cordyceps militaris polysaccharides can enhance the immunity and antioxidation activity in immunosuppressed mice Mi Wanga b Xin Yu Mengb Rui Le Yangb Tao Qina Xiao Yang Wangb Ke Yu Zhangb Chen Zhong Feib Ying Lib Yuan liang Hua Fei Qun Xueb a Institute of Traditional Chinese Veterinary Medicine College of Veterinary Medicine Nanjing Agricultural University Nanjing 210095 PR China b Department of Pharmacy Shanghai Veterinary Research Institute Chinese Academy of Agricultural Sciences Shanghai 200241 PR China ARTICLE INFO ABSTRACT Article history Received 18 January 2012 Received in revised form 28 February 2012 Accepted 8 March 2012 Available online 19 March 2012 Keywords Cordyceps militaris polysaccharides Cyclophosphamide-induced immunosuppression Immunomodulation Anti-oxidation activity in vivo To evaluate the immune activation and reactive oxygen species scavenging activity of Cordyceps mili-taris polysaccharides CMP in vivo 90 male BALB c mice were randomly divided into six groups. The mice in the three experimental groups were given cyclophosphamide at 80mg kg d via intraperitoneal injection and 17.5 35 or 70mg kg body weight CMP via gavage. The lymphocyte proliferation phagocytic index and biochemical parameters were measured. The results show that the administration of CMP was able to overcome the CY-induced immunosuppression significantly increased the spleen and thymus indices and enhanced the spleen lymphocyte activity and macrophage function. CMP can also improve the antioxidation activity in immunosuppressed mice significantly increase the superoxidase dismutase catalase and glutathione peroxidase levels and the total antioxidant capacity and decrease the malondialdehyde levels in vivo. 2012 Elsevier Ltd. All rights reserved. 1. Introduction In recent years many natural polysaccharides and .
