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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Correlation between endothelial function and carotid atherosclerosis in rheumatoid arthritis patients with long-standing disease. | González-Juanatey et al. Arthritis Research Therapy 2011 13 R101 http arthritis-research.eom content 13 3 R101 RESEARCH ARTICLE Open Access Correlation between endothelial function and carotid atherosclerosis in rheumatoid arthritis patients with long-standing disease Carlos Gonzalez-Juanatey1 Javier Llorca2 and Miguel A González-Gay3 Abstract Introduction In this study we aimed to determine the relationship between flow-mediated endotheliumdependent vasodilatation FMD and carotid artery intima-media wall thickness IMT two surrogate markers of atherosclerosis in a series of Spanish patients with rheumatoid arthritis RA without clinically evident cardiovascular CV disease. Methods One hundred eighteen patients who fulfilled the 1987 American College of Rheumatology classification criteria for RA had no history of CV disease and had at least one year of follow-up after disease diagnosis were randomly selected. Brachial and carotid ultrasonography were performed to determine FMD and carotid IMT respectively. Results Carotid IMT values were higher and FMD percentages derived by performing ultrasonography were lower in individuals with a long duration from the time of disease diagnosis. Patients with a disease duration 7 years had significantly lower carotid IMT mean SD 0.69 0.17 mm than those with long disease duration 0.81 0.12 mm in patients with 20 years of follow-up . Also patients with a long disease duration had severe endothelial dysfunction FMD 4.0 4.0 in patients with disease duration from 14.5 to 19.7 years compared with those with shorter disease duration FMD 7.4 3.8 in patients with disease duration 7 years . Linear regression analysis revealed that carotid IMT was unrelated to FMD in the whole sample of 118 patients. However carotid IMT was negatively associated with FMD when the time from disease diagnosis ranged from 7.5 to 19.7 years P 0.02 . Conclusions In patients with RA without CV disease endothelial dysfunction and carotid IMT increased with the .
