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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Simvastatin protects bladder and renal functions following spinal cord injury in rats. | Shunmugavel et al. Journal of Inflammation 2010 7 17 http www.journal-inflammation.eom content 7 1 17 JOURNAL OF INFLAMMATION RESEARCH Open Access Simvastatin protects bladder and renal functions following spinal cord injury in rats Anandakumar Shunmugavel 1 Mushfiquddin Khan1 Peter C te Chou2 Ramanpreet K Dhindsa1 Marcus M Martin3 Anne G Copay3 Brian R Subach3 Thomas C Schuler3 Mehmet Bilgen2 John KOrak1 and Inderjit Singh 1 Abstract Background Urinary bladder and renal dysfunction are secondary events associated with spinal cord injury SCI in humans. These secondary events not only compromise quality of life but also delay overall recovery from SCI pathophysiology. Furthermore in experimental models the effects of SCI therapy on bladder and renal functions are generally not evaluated. In this study we tested whether simvastatin improves bladder and renal functions in a rat model of experimental SCI. Methods SCI was induced by controlled contusion of T9-T10 in adult female rats. Simvastatin 5 mg Kg body weight was administered at two hours after SCI and repeated every 24 hours until the end point. Simvastatin-treated SCI animals simvastatin group were compared with vehicle-treated SCI animals vehicle group in terms of the Basso Beattie Bresnahan score tissue morphology cell death and bladder renal functions. Results The urinary bladder of vehicle animals showed a 4.3-fold increase in size and a 9-fold increase in wet weight compared to sham animals. Following SCI the urine to plasma osmolality ratio increased initially but decreased 1 week after SCI. Hematoxylin and eosin staining of bladder tissue showed transitional epithelial hyperplasia degeneration of lamina propria and enlargement of tunica adventia in addition to detrusor muscle hypertrophy. Rats treated with simvastatin for 14 days displayed remarkable recovery by showing decreased bladder size and maintenance of a normal urine plasma osmolality ratio in addition to improved locomotion. The muscularis .
