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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: Pharmacology of airways and vessels in lung slices in situ: role of endogenous dilator hormones. | Respiratory Research BioMed Central Research Pharmacology of airways and vessels in lung slices in situ role of endogenous dilator hormones L Moreno F Perez-Vizcaino L Harrington R Faro G Sturton PJ Barnes and JA Mitchell Open Access Address Cardiothoracic Pharmacology and Airway Disease Section National Heart Lung Institute Imperial College London Dovehouse Street SW3 6LY UK Email L Moreno - lmoreno@ift.csic.es F Perez-Vizcaino - fperez@med.ucm.es L Harrington - l.harrington@qmul.ac.uk R Faro - rfaro@cartesius.com G Sturton - g.sturton@imperial.ac.uk PJ Barnes - p.j.barnes@imperial.ac.uk JA Mitchell - j.a.mitchell@ic.ac.uk Corresponding author Published 21 August 2006 Received 25 January 2006 Respiratory Research 2006 7 111 doi 10.1186 1465-9921-7-111 Accepted 21 August 2006 This article is available from http respiratory-research.cOm content 7 l l I I 2006 Moreno et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Small airway and vessels play a critical role in chronic airway and pulmonary vascular diseases but their pharmacology has not been well characterised. We have studied airway and vascular responses in rat lung slices and separately in vitro using myography. In lung slices under basal conditions acetylcholine contracted airways but had no vascular effect. The thromboxane mimetic U46619 contracted both vessels and airways. In the presence of U46619 acetylcholine dilated vessels but further contracted airways an effect that was blocked by the nitric oxide synthase inhibitor L-NG-nitro-L-arginine or apamin plus charybdotoxin which inhibit endothelial-derived hyperpolarising factor. Airway responses in lung slices were unaffected by L-NGnitro-L-arginine methyl ester indomethacin or apamin plus .
