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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:" Susceptibility to ozone-induced airway inflammation is associated with decreased levels of surfactant protein D. | BioMed Central Respiratory Research Research Open Access Susceptibility to ozone-induced airway inflammation is associated with decreased levels of surfactant protein D S Kierstein1 FR Poulain2 Y Cao1 M Grous3 R Mathias2 G Kierstein1 MF Beers1 M Salmon3 RA Panettieri Jr1 and A Haczku 1 Address University of Pennsylvania Philadelphia PA USA 2University of California Davis CA USA and 3GSK King of Prussia PA USA Email S Kierstein - sonjak@mail.med.upenn.edu FR Poulain - frpoulain@ucdavis.edu Y Cao - yangcaosha@yahoo.com M Grous - Marilyn.Grous@gsk.com R Mathias - flipmuzik@yahoo.com G Kierstein - gkierstein@mac.com MF Beers - mfbeers@mail.med.upenn.edu M Salmon - Michael.2.Salmon@gsk.com RA Panettieri - rap@mail.med.upenn.edu AHaczku - haczku@mail.med.upenn.edu Corresponding author Published 01 June 2006 Received 22 February 2006 Respiratory Research 2006 7 85 doi l0.ll86 l465-992l-7-85 Accepted 0I June 2006 This article is available from http respiratory-research.cOm content 7 l 85 2006 Kierstein et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Ozone O3 a common air pollutant induces exacerbation of asthma and chronic obstructive pulmonary disease. Pulmonary surfactant protein SP -D modulates immune and inflammatory responses in the lung. We have shown previously that SP-D plays a protective role in a mouse model of allergic airway inflammation. Here we studied the role and regulation of SP-D in O3-induced inflammatory changes in the lung. Methods To evaluate the effects of O3 exposure in mouse strains with genetically different expression levels of SP-D we exposed Balb c C57BL 6 and SP-D knockout mice to O3 or air. BAL cellular and cytokine content and SP-D levels were evaluated and compared between
