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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:" Role of apoptosis in the pathogenesis of COPD and pulmonary emphysema. | Respiratory Research BioMed Central Review Open Access Role of apoptosis in the pathogenesis of COPD and pulmonary emphysema Ingel K Demedts Tine Demoor Ken R Bracke Guy F Joos and Guy G Brusselle Address Department of Respiratory Diseases Ghent University Hospital Belgium Email Ingel K Demedts - M.DemedtsIngelK@UGent.be Tine Demoor - tine.demoor@UGent.be Ken R Bracke - ken.bracke@UGent.be Guy F Joos - guy.joos@UGent.be Guy G Brusselle - Guy.Brusselle@UGent.be Corresponding author Published 30 March 2006 Received 13 December 2005 Respiratory Research 2006 7 53 doi l0.ll86 l465-992l-7-53 Accepted 30 March 2006 This article is available from http respiratory-research.cOm content 7 l 53 2006 Demedts et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Chronic obstructive pulmonary disease COPD is characterised by chronic inflammation of the airways and progressive destruction of lung parenchyma a process that in most cases is initiated by cigarette smoking. Several mechanisms are involved in the development of the disease influx of inflammatory cells into the lung leading to chronic inflammation of the airways imbalance between proteolytic and anti-proteolytic activity resulting in the destruction of healthy lung tissue and oxidative stress. Recently an increasing number of data suggest a fourth important mechanism involved in the development of COPD apoptosis of structural cells in the lung might possibly be an important upstream event in the pathogenesis of COPD. There is an increase in apoptotic alveolar epithelial and endothelial cells in the lungs of COPD patients. Since this is not counterbalanced by an increase in proliferation of these structural cells the net result is destruction of lung tissue and the .
