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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: "Cigarette smoke exposure facilitates allergic sensitization in mice. | Respiratory Research BioMed Central Research Open Access Cigarette smoke exposure facilitates allergic sensitization in mice Katrien B Moerloose Lander J Robays Tania Maes Guy G Brusselle Kurt G Tournoy and Guy F Joos Address Department of Respiratory Diseases Ghent University Hospital Ghent Belgium Email Katrien B Moerloose - katrien.moerloose@ugent.be Lander J Robays - lander.robays@ugent.be Tania Maes - tania.maes@ugent.be Guy G Brusselle - guy.brusselle@ugent.be Kurt G Tournoy - kurt.tournoy@ugent.be Guy F Joos - guy.joos@ugent.be Corresponding author Published 29 March 2006 Received 23 December 2005 Respiratory Research2006 7 49 doi l0.ll 86 1465-9921 -7-49 Accepted 29 March 2006 This article is available from http respiratory-research.cOm content 7 1 49 2006Moerloose et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Active and passive smoking are considered as risk factors for asthma development. The mechanisms involved are currently unexplained. Objective The aim of this study was to determine if cigarette smoke exposure could facilitate primary allergic sensitization. Methods BALB c mice were exposed to aerosolized ovalbumin OVA combined with air or tobacco smoke 4 exposures day daily for three weeks. Serology lung cytopathology cytokine profiles in bronchoalveolar lavage fluid BALF and on mediastinal lymph node cultures as well as lung function tests were performed after the last exposure. The natural history and the immune memory of allergic sensitization were studied with in vivo recall experiments. Results Exposure to OVA induced a small increase in OVA-specific serum IgE as compared with exposure to PBS P 0.05 while no inflammatory reaction was observed in the airways. Exposure to .
