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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Bone mineral density and body composition in postmenopausal women with psoriasis and psoriatic arthritis. | Pedreira et al. Arthritis Research Therapy 2011 13 R16 http arthritis-research.eom content 13 1 R16 RESEARCH ARTICLE Open Access Bone mineral density and body composition in postmenopausal women with psoriasis and psoriatic arthritis Paulo G Pedreira Marcelo M Pinheiro Vera L Szejnfeld Abstract Introduction The aim of the present study was to compare bone mineral density BMD and body composition BC measurements as well as identify risk factors for low BMD and osteoporotic fractures in postmenopausal women with psoriasis Ps and psoriatic arthritis PsA . Methods A cross-sectional study was carried out in 45 PsA women 52 Ps women and 98 healthy female controls HC . Clinical risk factors for low bone density and osteoporotic fracture were evaluated by a specific questionnaire. An X-ray absorptiometry DXA at the lumbar spine total femur and total body was performed on all patients. Skin and joint outcomes were measured by specific tools PASI HAQ and DAS28 . Morphometric vertebral fractures were evaluated by lumbar and thoracic spine X-ray according to Genant s method. Results There were no significant differences in age body mass index BMI total lean mass and bone mineral density among the groups. However the PsA group had a significantly higher body fat percentage BF than the Ps and HC groups. Osteoporotic fractures were more frequently observed in PsA and Ps groups than in the HC group P 0.01 . Recurrent falls and a longer duration of disease increased the risk of fracture odds ratio OR 18.3 and 1.08 respectively in the PsA group P 0.02 . Disability was the main factor related to osteoporotic fracture in the Ps group odds ratio OR 11.1 P 0.02 . Conclusions Ps and PsA patients did not present lower BMD. However they had a higher prevalence of osteoporotic fractures and higher risk of metabolic syndrome. Patients with a longer duration of disease disability and recurrent falls need preventive measures. Introduction Psoriasis Ps and psoriatic arthritis PsA are chronic .
