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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: Phosphodiesterase type 4 expression and anti-proliferative effects in human pulmonary artery smooth muscle cells. | Respiratory Research BioMed Central Research Open Access Phosphodiesterase type 4 expression and anti-proliferative effects in human pulmonary artery smooth muscle cells Ellena J Growcott1 Karen G Spink2 Xiaohui Ren1 Saliha Afzal1 3 Kathy H Banner2 4 and John Wharton 1 Address 1Section on Experimental Medicine and Toxicology Imperial College London Hammersmith Campus Du Cane Road London W12 0NN UK 2Pfizer Global Research and Development Discovery Biology Ramsgate Road Sandwich Kent CT13 9NJ UK 3MRC London Neurodegenerative Diseases Brain Bank Institute of Psychiatry Windsor Walk London SE5 8AF UK and 4Novartis Institute for BioMedical Research Wimblehurst Road Horsham West Sussex RH12 5AB UK Email Ellena J Growcott - ellena.growcott@imperial.ac.uk Karen G Spink - karen.spink@pfizer.com Xiaohui Ren - xh_ren@hotmail.com Saliha Afzal - S.Afzal@iop.kcl.ac.uk Kathy H Banner - kathy.banner@novartis.com John Wharton - j.wharton@imperial.ac.uk Corresponding author Published 19 January 2006 Received 01 November 2005 Respiratory Research 2006 7 9 doi l0.ll86 l465-992l-7-9 Accepted 19 January 2006 This article is available from http respiratory-research.cOm content 7 l 9 2006 Growcott et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Pulmonary arterial hypertension is a proliferative vascular disease characterized by aberrant regulation of smooth muscle cell proliferation and apoptosis in distal pulmonary arteries. Prostacyclin PGI2 analogues have anti-proliferative effects on distal human pulmonary artery smooth muscle cells PASMCs which are dependent on intracellular cAMP stimulation. We therefore sought to investigate the involvement of the main cAMP-specific enzymes phosphodiesterase type 4 PDE4 responsible
