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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " Nontypeable Haemophilus influenzae induces COX-2 and PGE2 expression in lung epithelial cells via activation of p38 MAPK and NF-kappa B. | Respiratory Research BioMed Central Research Open Access Nontypeable Haemophilus influenzae induces COX-2 and PGE2 expression in lung epithelial cells via activation of p38 MAPK and NF-kappa B Feng Xu1 Zhihao Xu1 Rong Zhang2 Zuqun Wu1 Jae-Hyang Lim3 Tomoaki Koga3 Jian-Dong Li3 and Huahao Shen 1 Address Department of Respiratory Medicine Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou Zhejiang 310009 China 2Center of Clinical Laboratories Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou Zhejiang 310009 China and 3Department of Microbiology Immunology University of Rochester Medical Center Rochester 14642 USA Email Feng Xu - xufeng99@yahoo.com Zhihao Xu - zhihaox@sina.com Rong Zhang - brigitte_zx@163.com Zuqun Wu - wuzuqun522@sohu.com Jae-Hyang Lim - Jae-Hyang_Lim@urmc.rochest.edu Tomoaki Koga - tomoaki_koga@urmc.rochester.edu Jian-Dong Li - jian-dong_li@urmc.rochest.edu Huahao Shen - hh_shen@yahoo.com.cn Corresponding author Published 31 January 2008 Received 23 July 2007 Respiratory Research 2008 9 16 doi 10.1186 1465-9921-9-16 Accepted 31 January 2008 This article is available from http respiratory-research.cOm content 9 1 16 2008 Xu et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Nontypeable Haemophilus influenzae NTHi is an important respiratory pathogen implicated as an infectious trigger in chronic obstructive pulmonary disease but its molecular interaction with human lung epithelial cells remains unclear. Herein we tested that the hypothesis that NTHi induces the expression of cyclooxygenase COX -2 and prostaglandin E2 PGE2 via activation of p38 mitogen-activated protein kinase MAPK and nuclear factor NF -kappa B in pulmonary alveolar .
