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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: The association between leptin, interleukin-6, and hip radiographic osteoarthritis in older people: a cross-sectional study. | Stannus et al. Arthritis Research Therapy 2010 12 R95 http arthritis-research.eom content 12 3 R95 RESEARCH ARTICLE Open Access The association between leptin interleukin-6 and hip radiographic osteoarthritis in older people a cross-sectional study Oliver P Stannus 1 Graeme Jones1 Stephen J Quinn1 Flavia M Cicuttini2 Dawn Dore1 and Changhai Ding 1 2 Abstract Introduction The associations between leptin interleukin IL -6 and hip radiographic osteoarthritis OA have not been reported and their roles in obesity-related hip OA are unclear. The aim of this study was to describe the associations between leptin IL-6 and hip radiographic osteoarthritis ROA in older adults. Methods A cross-sectional sample of 193 randomly selected subjects mean age 63 years range 52 to 78 years 48 female subjects were studied. Hip ROA including joint-space narrowing JSN and osteophytes was determined by anteroposterior radiograph. Serum levels of leptin and interleukin IL -6 were measured with radioimmunoassay. Fat mass was measured with dual-energy x-ray absorptiometry DXA . Body mass index BMI and waist-to-hip ratio WHR were calculated. Results In multivariable analysis hip JSN was associated with serum levels of leptin in the whole sample P 0.046 per pg L P 0.024 for superior P 0.068 per pg L P 0.004 for axial compartment and IL-6 only in females P 0.241 per pg ml P 0.002 for superior P 0.239 per pg ml P 0.001 for axial compartment . The positive associations between body-composition measures BMI WHR percentage total fat mass and percentage trunk fat mass and hip JSN in women became nonsignificant after adjustment for leptin but not for IL-6. No significant associations were found between leptin IL-6 and the presence or severity of osteophytes. Conclusions This study suggests that metabolic and inflammatory mechanisms may play a role in the etiology of hip OA and that the associations between body composition and hip JSN are mediated by leptin particularly in women. Introduction .
