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Báo cáo y học: "Respiratory syncytial virus infection is associated with an altered innate immunity and a heightened "

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:"Respiratory syncytial virus infection is associated with an altered innate immunity and a heightened. | Sow et al. Respiratory Research 2011 12 106 http respiratory-research.eom content 12 1 106 RESPIRATORY RESEARCH RESEARCH Open Access Respiratory syncytial virus infection is associated with an altered innate immunity and a heightened pro-inflammatory response in the lungs of preterm lambs Fatoumata B Sow1 Jack M Gallup1 Subramaniam Krishnan2 Andriani C Patera2 JoAnn Suzich2 and Mark R Ackermann1 Abstract Introduction Factors explaining the greater susceptibility of preterm infants to severe lower respiratory infections with respiratory syncytial virus RSV remain poorly understood. Fetal newborn lambs are increasingly appreciated as a model to study key elements of RSV infection in newborn infants due to similarities in lung alveolar development immune response and susceptibility to RSV. Previously our laboratory demonstrated that preterm lambs had elevated viral antigen and developed more severe lesions compared to full-term lambs at seven days post-infection. Here we compared the pathogenesis and immunological response to RSV infection in lungs of preterm and full-term lambs. Methods Lambs were delivered preterm by Caesarian section or full-term by natural birth then inoculated with bovine RSV bRSV via the intratracheal route. Seven days post-infection lungs were collected for evaluation of cytokine production histopathology and cellular infiltration. Results Compared to full-term lambs lungs of preterm lambs had a heightened pro-inflammatory response after infection with significantly increased MCP-1 MIP-1a IFN-y TNF-a and PD-L1 mRNA. RSV infection in the preterm lung was characterized by increased epithelial thickening and periodic acid-Schiff staining indicative of glycogen retention. Nitric oxide levels were decreased in lungs of infected preterm lambs compared to full-term lambs indicating alternative macrophage activation. Although infection induced significant neutrophil recruitment into the lungs of preterm lambs neutrophils produced less myeloperoxidase .