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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " Disparate oxidant gene expression of airway epithelium compared to alveolar macrophages in smokers. | Respiratory Research BioMed Central Research Disparate oxidant gene expression of airway epithelium compared to alveolar macrophages in smokers Brendan J Carolan1 2 Ben-Gary Harvey1 2 Neil R Hackett1 Timothy P O Connor1 Patricia A Cassano3 and Ronald G Crystal 1 2 Open Access Address Department of Genetic Medicine Weill Cornell Medical College New York New York USA 2Division of Pulmonary and Critical Care Medicine Weill Cornell Medical College New York New York USA and 3Division of Nutritional Sciences Cornell University Ithaca New York USA Email Brendan J Carolan - geneticmedicine@med.cornell.edu Ben-Gary Harvey - geneticmedicine@med.cornell.edu Neil R Hackett - geneticmedicine@med.cornell.edu Timothy P O Connor - geneticmedicine@med.cornell.edu Patricia A Cassano - geneticmedicine@med.cornell.edu Ronald G Crystal - geneticmedicine@med.cornell.edu Corresponding author Published 17 November 2009 Received 8 June 2009 Accepted 17 November 2009 Respiratory Research 2009 10 111 doi l0.ll86 l465-992l-l0-lll r This article is available from http respiratory-research.cOm content l0 l l ll 2009 Carolan et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The small airway epithelium and alveolar macrophages are exposed to oxidants in cigarette smoke leading to epithelial dysfunction and macrophage activation. In this context we asked what is the transcriptome of oxidant-related genes in small airway epithelium and alveolar macrophages and does their response differ substantially to inhaled cigarette smoke Methods Using microarray analysis with TaqMan RT-PCR confirmation we assessed oxidant-related gene expression in small airway epithelium and alveolar macrophages from the same healthy nonsmoker and smoker .
