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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:" Pulmonary fibrosis induced by H5N1 viral infection in mice. | Respiratory Research BioMed Central Research Pulmonary fibrosis induced by H5NI viral infection in mice Jian Qiao f Miaojie Zhangt Jianmin Bit Xun Wangt Guangcun Deng Guimei He Zhihua Luan Nana Lv Tong Xu and Lihong Zhao Open Access Address Department of Pathophysiology College of Veterinary Medicine China Agricultural University Beijing 100193 PR China Email Jian Qiao - qiaojian@cau.edu.cn Miaojie Zhang - zhangmiaojie52@hotmail.com Jianmin Bi - bjmminer@163.com Xun Wang - liushui198252@163.com Guangcun Deng - dgc@nxu.edu.cn Guimei He - guimeihe@163.com Zhihua Luan - lzh4215@eyou.com Nana Lv - 5sggt@163.com Tong Xu - xutong1969@sohu.com Lihong Zhao - zhlhong@cau.edu.cn Corresponding authors tEqual contributors Published 12 November 2009 Received 13 March 2009 Respiratory Research 2009 10 107 doi l0.ll86 l465-992l-l0-l07 Accepted 12 November 2009 This article is available from http respiratory-research.com content l0 l l07 2009 Qiao et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Inflammatory process results in lung injury that may lead to pulmonary fibrosis PF . Here we described PF in mice infected with H5Nl virus. Methods Eight-week-old BALB c mice were inoculated intranasally with l X l0l MID50 of A Chicken Hebei l08 2002 H5Nl viruses. Lung injury fibrosis was evaluated by observation of hydroxyproline concentrations lung indexes and histopathology on days 7 l4 and 30 postinoculation. Results H5Nl-inoculated mice presented two stages of pulmonary disease over a 30-d period after infection. At acute stage infected-mice showed typical diffuse pneumonia with inflammatory cellular infiltration alveolar and interstitial edema and hemorrhage on day 7 postinoculation. At restoration stage most .