Đang chuẩn bị nút TẢI XUỐNG, xin hãy chờ
Tải xuống
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:" Serum adiponectin is positively associated with lung function in young adults, independent of obesity: The CARDIA study. | Thyagarajan et al. Respiratory Research 2010 11 176 http respiratory-research.eom content 11 1 176 RESPIRATORY RESEARCH RESEARCH Open Access Serum adiponectin is positively associated with lung function in young adults independent of obesity The CARDIA study c r. I 1 S I - n 11 Ì -A V 11 u D I -A r l-A r I v 2 3 I A A I r I c m if P4 Da À Iz I I nr 4 A r A A I Ì r r f A r r 1 A l r In c A A A A u5 Bharat ihyagarajan David R Jacobs Jr Lewis J Smith Ravi I aman Myron D Gross AKsnay Sood Abstract Rationale Adipose tissue produces adiponectin an anti-inflammatory protein. Adiponectin deficiency in mice is associated with abnormal post-natal alveolar development. Objective We hypothesized that lower serum adiponectin concentrations are associated with lower lung function in humans independent of obesity. We explored mediation of this association by insulin resistance and systemic inflammation. Methods and Measurements Spirometry testing was conducted at years 10 and 20 follow-up evaluation visits in 2 056 eligible young adult participants in the Coronary Artery Risk Development in Young Adults CARDIA study. Body mass index serum adiponectin serum C-reactive protein a marker of systemic inflammation and insulin resistance were assessed at year 15. Main Results After controlling for body mass index years 10 and 20 forced vital capacity FVC were 81 ml and 82 ml lower respectively p 0.004 and 0.01 respectively in the lowest vs. highest adiponectin quartiles. Similarly years 10 and 20 forced expiratory volume in one second FEV1 were 50 ml and 38 ml lower p 0.01 and 0.09 respectively in the lowest vs. highest adiponectin quartiles. These associations were no longer significant after adjustment for insulin resistance and C-reactive protein. Serum adiponectin was not associated with FEV1 FVC or peak FEV1. Conclusions Independent of obesity lower serum adiponectin concentrations are associated with lower lung function. The attenuation of this association after adjustment for .
