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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:" Extracellular Hsp72, an endogenous DAMP, is released by virally infected airway epithelial cells and activates. | Respiratory Research BioMed Central Research Extracellular Hsp72 an endogenous DAMP is released by virally infected airway epithelial cells and activates neutrophils via Toll-like receptor TLR -4 Derek S Wheeler1 2 Margaret A Chase1 Albert P Senft3 Sue E Poynter1 2 Hector R Wong1 2 and Kristen Page 1 2 Open Access Address division of Critical Care Medicine Cincinnati Children s Hospital Medical Center Cincinnati Children s Research Foundation Cincinnati OH USA 2Department of Pediatrics University of Cincinnati College of Medicine Cincinnati OH USA and infectious Diseases Program Lovelace Respiratory Research Institute Albuquerque New Mexico USA Email Derek S Wheeler - derek.wheeler@cchmc.org Margaret A Chase - chasem@pediatrics.ohio-state.edu Albert P Senft - asenft@lrri.org Sue E Poynter - sue.poynter@cchmc.org Hector R Wong - hector.wong@cchmc.org Kristen Page - kristen.page@cchmc.org Corresponding author Published 30 April 2009 Received 16 December 2008 Respiratory Research 2009 10 31 doi 10.1186 1465-9921-10-31 Accepted 30 April 2009 This article is available from http respiratory-research.com content 10 1 31 2009 Wheeler et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.Org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Neutrophils play an important role in the pathophysiology of RSV though RSV does not appear to directly activate neutrophils in the lower airways. Therefore locally produced cytokines or other molecules released by virally-infected airway epithelial cells are likely responsible for recruiting and activating neutrophils. Heat shock proteins HSPs are generally regarded as intracellular proteins acting as molecular chaperones however HSP72 can also be released from cells and the implications of this release are not fully understood.
