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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:" Characterisation of the proximal airway squamous metaplasia induced by chronic tobacco smoke exposure in spontaneously hypertensive rat. | Respiratory Research BioMed Central Open Access Characterisation of the proximal airway squamous metaplasia induced by chronic tobacco smoke exposure in spontaneously hypertensive rats Sarah J Bolton 11 Kate Pinnion11 Victor Oreffo1 Martyn Foster1 and Kent E Pinkerton2 Address 1Safety Assessment UK AstraZeneca R D Charnwood Bakewell Road Loughborough Leicestershire LE11 5RH UK and 2Centre for Health and Environment University of California Davis CA 95616 USA Email Sarah J Bolton - sarahj.bolton@astrazeneca.com Kate Pinnion - kate.pinnion@astrazeneca.com Victor Oreffo - victor.oreffo@astrazeneca.com Martyn Foster - martyn.foster@astrazeneca.com Kent E Pinkerton - kepinkerton@ucdavis.edu Corresponding author tEqual contributors Published 24 November 2009 Received 26 May 2009 Respiratory Research 2009 10 118 doi 10.1186 1465-9921-10-118 Accepted 24 November 2009 This article is available from http respiratory-research.cOm content 10 1 1 18 2009 Bolton et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Continuous exposure to tobacco smoke TS is a key cause of chronic obstructive pulmonary disease COPD a complex multifactorial disease that is difficult to model in rodents. The spontaneously hypertensive SH rat exhibits several COPD-associated co-morbidities such as hypertension and increased coagulation. We have investigated whether SH rats are a more appropriate animal paradigm of COPD. Methods SH rats were exposed to TS for 6 hours day 3 days week for 14 weeks and the lung tissues examined by immunohistochemistry. Results TS induced a CK13-positive squamous metaplasia in proximal airways which also stained for Ki67 and p63. We hypothesise that this lesion arises by basal cell proliferation which .
