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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:" Loss of a single N-linked glycan from the hemagglutinin of influenza virus is associated with resistance to collectins and increased virulence in mice. | Respiratory Research BioMed Central Research Loss of a single N-linked glycan from the hemagglutinin of influenza virus is associated with resistance to collectins and increased virulence in mice Patrick C Reading 1 2 Danielle L Pickett1 Michelle D Tate1 Paul G Whitney1 Emma R Job1 and Andrew G Brooks1 Open Access Address Department of Microbiology and Immunology The University of Melbourne Parkville 3010 Victoria Australia and 2WHO Collaborating Centre for Reference and Research on Influenza North Melbourne 3051 Victoria Australia Email Patrick C Reading - preading@unimelb.edu.au Danielle L Pickett - dpickett@unimelb.edu.au Michelle D Tate - m.tate@pgrad.unimelb.edu.au Paul G Whitney - whitneyp@unimelb.edu.au Emma R Job - e.job@pgrad.unimelb.edu.au Andrew G Brooks - agbrooks@unimelb.edu.au Corresponding author Published 23 November 2009 Received 4 July 2009 Accepted 23 November 2009 Respiratory Research 2009 10 117 doi 10.1186 1465-9921-10-117 r This article is available from http respiratory-research.com content 10 1 1 17 2009 Reading et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Glycosylation on the globular head of the hemagglutinin HA protein of influenza virus acts as an important target for recognition and destruction of virus by innate immune proteins of the collectin family. This in turn modulates the virulence of different viruses for mice. The role of particular oligosaccharide attachments on the HA in determining sensitivity to collectins has yet to be fully elucidated. Methods When comparing the virulence of H3N2 subtype viruses for mice we found that viruses isolated after 1980 were highly glycosylated and induced mild disease in mice. During these studies we were surprised to find
