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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " The cytokine-driven regulation of secretoglobins in normal human upper airway and their expression, particularly that of uteroglobin-related protein 1, in chronic rhinosinusitis. | Lu et al. Respiratory Research 2011 12 28 http respiratory-research.eom content 12 1 28 RESPIRATORY RESEARCH RESEARCH Open Access The cytokine-driven regulation of secretoglobins in normal human upper airway and their expression particularly that of uteroglobin-related protein 1 in chronic rhinosinusitis Xiang Lu Nan Wang Xiao-Bo Long Xue-Jun You Yong-Hua Cui Zheng Liu Abstract Background The involvement of secretoglobins SCGBs other than SCGB1A1 Clara cell 10-kDa protein CC10 in human airway diseases remains unexplored. Among those SCGBs SCGB3A2 uteroglobin-related protein 1 UGRP1 is particularly interesting given its structure and function similarities with SCGB1A1 CC10 . The aim of this study was to investigate the expression regulation of SCGBs other than SCGB1A1 CC10 in human upper airway and their potential involvement particularly that of SCGB3A2 UGRP1 in chronic rhinosinusitis CRS with nasal polyps CRSwNP and without nasal polyps CRSsNP . Methods Eight SCGB family members including SCGB3A2 UGRP1 SCGB1C1 ligand binding protein RYD5 SCGB1D1 lipophilin A SCGB1D2 lipophilin B SCGB1D4 interferon-g inducible SCGB SCGB2A1 mammaglobin 2 SCGB2A2 mammaglobin 1 and SCGB3A1 uteroglobin-related protein 2 were studied. The regulation of SCGBs mRNA expression in normal nasal mucosa by proinflammatory Th1 and Th2 cytokines was studied through nasal explant culture. SCGBs mRNA expression levels in CRSsNP and CRSwNP patients and controls were compared. The mRNA levels were detected by means of quantitative reverse transcriptase-polymerase chain reaction. The protein expression of SCGB3A2 UGRP1 was analyzed using immunohistochemistry. Results The expression of SCGBs except SCGB1D2 lipophilin B could be found in upper airway and be differentially regulated by different cytokines. SCGB3A2 UGRP1 mRNA expression was induced by Th1 cytokine but suppressed by proinflammatory and Th2 cytokines. SCGBs mRNA expression was altered in CRS particularly SCGB3A2 UGRP1 protein and mRNA .
