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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Pharmacokinetics of Linezolid and Ertapenem in experimental parapneumonic pleural effusion. | Saroglou et al. Journal of Inflammation 2010 7 22 http www.journal-inflammation.eom content 7 1 22 JOURNAL OF INFLAMMATION RESEARCH Open Access PhaCrmacokinetics of Linezolid and Ertapenem in experimental parapneumonic pleural effusion Maria Saroglou1 Stavros Tryfon1 Georgios Ismailos2 loannis Liapakis3 ManolisTzatzarakis4 Aristidis Tsatsakis4 Apostolos Papalois2 and Demosthenes Bouros 3 Abstract Objective To determine the extent of linezolid and ertapenem penetration into the empyemic fluid using a rabbit model of empyema. Methods An empyema was created via the intrapleural injection of Escherichia coli bacteria ATCC 35218 into the pleural space of New Zealand white rabbits. After an empyema was verified by thoracocentesis 24 hours post inoculation linezolid 10 mg kg and ertapenem 60 mg kg were administered intravenously into 10 and 8 infected empyemic rabbits respectively. Antibiotic levels were determined in samples of pleural fluid and blood serum collected serially at 1 2 4 6 and 8 hours after administration each of the two antibiotics. Results Linezolid as well as ertapenem penetrate well into the empyemic pleural fluid exhibiting a slower onset and decline compared to the corresponding blood serum levels. Equilibration between blood serum and pleural fluid compartments seems to occur at 1.5 hours for both linezolid and ertapenem with peak pleural fluid levels Cmaxpf of 2.02 0.73 mu g ml and Cmaxpf of 3.74 1.39 mu g ml correspondingly occurring 2 hours post antibiotics administration and decreasing very slowly thereafter. The serum concentrations for both antibiotics were significantly lower from the corresponding pleural fluid ones during the 8 hours collecting data with the exception of samples collected at the 1st hour Cmaxserum of 2.1 1.2 mu g ml for linezolid and Cmaxserum of 6.26 2.98 mu g ml for ertapenem . Conclusion Pleural fluid levels of both antibiotics are inhibitory for common specified pathogens causing empyema. Introduction The annual .
