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In our study, we aimed to determine the validity of diagnostic methods for tuberculosis. Eighty-one people suspected to have tuberculosis were included in the study. The validity of the applied methods for the diagnosis of tuberculosis tuberculin skin test (TST), sputum smear, and used in diagnostic chest X-ray findings (CXR), clinical features and history were evaluated as culture was considered the reference test. Included in the study of 81 people (54 males 27 females) mean age was determined as 45.04 ± 18.69. The most sensitive diagnostic methods were detected as clinical and sputum smears (89 and 86%). The sensitivity of PPD and Radiology have been identified. | African Journal of Microbiology Research Vol. 4 8 pp. 613-617 18 April 2010 Available online http www.academicjournals.org ajmr ISSN 1996-0808 2010 Academic Journals Full Length Research Paper The validity of the diagnostic methods in predicting pulmonary tuberculosis Sulhattin Arslan1 Levent Ozdemir2 Yeltekin Demirel3 and Ibrahim Akkurt1 Department of Chest Diseases Faculty of Medicine Cumhuriyet University 58140 Sivas Turkey. 2Department of Public Health Faculty of Medicine Cumhuriyet University 58140 Sivas Turkey. 3Department of Family Doctor Faculty of Medicine Cumhuriyet University 58140 Sivas Turkey. Accepted 12 March 2010 In our study we aimed to determine the validity of diagnostic methods for tuberculosis. Eighty-one people suspected to have tuberculosis were included in the study. The validity of the applied methods for the diagnosis of tuberculosis tuberculin skin test TST sputum smear and used in diagnostic chest X-ray findings CXR clinical features and history were evaluated as culture was considered the reference test. Included in the study of 81 people 54 males 27 females mean age was determined as 45.04 18.69. The most sensitive diagnostic methods were detected as clinical and sputum smears 89 and 86 . The sensitivity of PPD and Radiology have been identified as 0.74 and 0.73 respectively. Diagnostic method with the highest specificity value was found to be radiology. The positive predictive values of PPD radiology clinical and sputum smear were identified as 98 94 96 and 92 respectively. PPD had the lowest negative predictive value with 26 . In our study the validity of the diagnostic methods for the tuberculosis are compatible with the literature. These methods in the diagnosis of tuberculosis are still valid. We think our study may add to the current data in the literature about the topic. Key words Validity specificity sensitivity PPD TST sputum smear culture tuberculosis clinical features. INTRODUCTION Every year there are 8.8 million new .