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Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí hóa học đề tài : The health loss from ischemic stroke and intracerebral hemorrhage: evidence from the North East Melbourne Stroke Incidence Study (NEMESIS) | Cadilhac et al. Health and Quality of Life Outcomes 2010 8 49 http www.hqlo.eom content 8 1 49 I HEALTH AND QUALITY OF LIFE OUTCOMES RESEARCH Open Access The health loss from ischemic stroke and intracerebral hemorrhage evidence from the North East Melbourne Stroke Incidence Study NEMESIS Dominique A Cadilhac 1 2 3 Helen M Dewey1 2 4 Theo Vos5 Rob Carter3 and Amanda G Thrift1 6 7 Abstract Background People suffering different types of stroke have differing demographic characteristics and survival. However current estimates of disease burden are based on the same underlying assumptions irrespective of stroke type. We hypothesized that average Quality Adjusted Life Years QALYs lost from stroke would be different for ischemic stroke and intracerebral hemorrhage ICH . Methods We used 1 and 5-year data collected from patients with first-ever stroke participating in the North East Melbourne Stroke Incidence Study NEMESIS . We calculated case fatality rates health-adjusted life expectancy and quality-of-life QoL weights specific to each age and gender category. Lifetime health loss for first-ever ischemic stroke and ICH surviving 28-days for the 2004 Australian population cohort was then estimated. Multivariable uncertainty analyses and sensitivity analyses SA were used to assess the impact of varying input parameters e.g. case fatality and QoL weights. Results Paired QoL data at 1 and 5 years were available for 237 NEMESIS participants. Extrapolating NEMESIS rates 31 539 first-ever strokes were expected for Australia in 2004. Average discounted 3 QALYs lost per first-ever stroke were estimated to be 5.09 SD 0.20 SA 5.49 for ischemic stroke n 27 660 and 6.17 SD 0.26 SA 6.45 for ICH n 4 291 p 0.001 . QALYs lost also differed according to gender for both subtypes ischemic stroke males 4.69 SD 0.38 females 5.51 SD 0.46 ICH males 5.82 SD 0.67 females 6.50 SD 0.40 . Discussion People with ICH incurred greater loss of health over a lifetime than people with ischemic stroke. .
