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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: A Viral Platform for Chemical Modification and Multivalent Display | Journal of Nanobiotechnology BioMed Central Research Open Access A Viral Platform for Chemical Modification and Multivalent Display David S Peabody Address Department of Molecular Genetics and Microbiology and the Cancer Research and Treatment Center University of New Mexico School of Medicine Albuquerque New Mexico USA 87131 Email David S Peabody - dpeabody@salud.unm.edu Corresponding author Published 15 July 2003 Received 27 May 2003 Accepted 15 July 2003 Journal of Nanobiotechnology 2003 1 5 This article is available from http www.jnanobiotechnology.cOm content 1 1 5 2003 Peabody licensee BioMed Central Ltd. This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Abstract The ability to chemically modify the surfaces of viruses and virus-like particles makes it possible to confer properties that make them potentially useful in biotechnology nanotechnology and molecular electronics applications. RNA phages e.g. MS2 have characteristics that make them suitable scaffolds to which a variety of substances could be chemically attached in definite geometric patterns. To provide for specific chemical modification of MS2 s outer surface cysteine residues were substituted for several amino acids present on the surface of the wild-type virus particle. Some substitutions resulted in coat protein folding or stability defects but one allowed the production of an otherwise normal virus-like particle with an accessible sulfhydryl on its surface. Background The ability of viruses to self-assemble into nanoscale particles of discrete size and definite geometry gives them potential utility in a variety of nano- and biotechnology applications. Efforts to adapt icosahedral virus particles for use as templates for materials synthesis as platforms for the multivalent presentation of ligands and even as possible molecular electronic components .
