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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: The margination propensity of spherical particles for vascular targeting in the microcirculation | Journal of Nanobiotechnology BioMed Central Open Access The margination propensity of spherical particles for vascular targeting in the microcirculation Francesco Gentile1 Antonio Curcio2 Ciro Indolfi2 Mauro Ferrari3 4 and Paolo Decuzzi 1 3 Address 1Center of Bio- Nanotechnology and - Engineering for Medicine University of Magna Graecia at Catanzaro Viale Europa - Loc. Germaneto 88100 Catanzaro Italy 2Division of Cardiology University of Magna Graecia at Catanzaro Viale Europa - Loc. Germaneto 88100 Catanzaro Italy 3The University of Texas Health Science Center Houston 1825 Pressler St Houston Texas 77030 USA and 4M.D. Anderson Cancer Center and Rice University 1825 Pressler St Houston Texas 77030 USA Email Francesco Gentile - Paolo.Decuzzi@uth.tmc.edu Antonio Curcio - Paolo.Decuzzi@uth.tmc.edu Ciro Indolfi - Paolo.Decuzzi@uth.tmc.edu Mauro Ferrari - Paolo.Decuzzi@uth.tmc.edu Paolo Decuzzi - Paolo.Decuzzi@uth.tmc.edu Corresponding author Published 15 August 2008 Received 5 January 2008 Accepted 15 August 2008 Journal of Nanobiotechnology 2008 6 9 doi l0.ll86 l477-3l55-6-9 This article is available from http www.jnanobiotechnology.cOm content 6 l 9 2008 Gentile et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract The propensity of circulating particles to drift laterally towards the vessel walls margination in the microcirculation has been experimentally studied using a parallel plate flow chamber. Fluorescent polystyrene particles with a relative density to water of just 50 g cm3comparable with that of liposomal or polymeric nanoparticles used in drug delivery and bio-imaging have been used with a diameter spanning over three order of magnitudes from 50 nm up to 10 ụm. The number ns of particles marginating per .
