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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Intracellular gold nanoparticles enhance non-invasive radiofrequency thermal destruction of human gastrointestinal cancer cells | Journal of Nanobiotechnology BioMed Central Research Open Access Intracellular gold nanoparticles enhance non-invasive radiofrequency thermal destruction of human gastrointestinal cancer cells Christopher J Gannon1 Chitta Ranjan Patra2 Resham Bhattacharya2 Priyabrata Mukherjee2 and Steven A Curley 1 Address Department of Surgical Oncology University of Texas M. D. Anderson Cancer Center Houston Texas USA and 2The Department of Biomedical Engineering Mayo Clinic Rochester Minnesota USA Email Christopher J Gannon - gannoncj@umdnj.edu Chitta Ranjan Patra - Patra.Chittaranjan@mayo.edu Resham Bhattacharya - Bhattacharya.Resham@mayo.edu Priyabrata Mukherjee - Mukherjee.Priyabrata@mayo.edu Steven A Curley - scurley@mdanderson.org Corresponding author Published 30 January 2008 Received 8 August 2007 Accepted 30 January 2008 Journal of Nanobiotechnology 2008 6 2 doi 10.1186 1477-3155-6-2 This article is available from http www.jnanobiotechnology.cOm content 6 1 2 2008 Gannon et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Novel approaches to treat human cancer that are effective with minimal toxicity profiles are needed. We evaluated gold nanoparticles GNPs in human hepatocellular and pancreatic cancer cells to determine 1 absence of intrinsic cytotoxicity of the GNPs and 2 external radiofrequency RF field-induced heating of intracellular GNPs to produce thermal destruction of malignant cells. GNPs 5 nm diameter were added to 2 human cancer cell lines Panc-I Hep3B . 3- 4 5-Dimethylthiazol-2-yl -2 5-diphenyltetrazolium bromide MTT assay and propidium iodide-fluorescence associated cell sorting PI-FACS assessed cell proliferation and GNP-related cytotoxicity. Other GNP-treated cells were exposed to a 13.56 .
