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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: The ‘RASor’s’ edge: Ras proteins and matrix destruction in arthritis. | Available online http arthritis-research.eom content 11 6 136 Editorial The RASor s edge Ras proteins and matrix destruction in arthritis Adam C Schmucker1 and Constance E Brinckerhoff1 2 1 Department of Biochemistry Dartmouth Medical School North College Street 7200 Vail Building Hanover NH 03755 USA 2Department of Medicine Dartmouth-Hitchcock Medical Center Lebanon NH 03756 USA Corresponding author Constance E Brinckerhoff brinckerhoff@dartmouth.edu Published 11 December 2009 Arthritis Research Therapy 2009 11 136 doi 10.1186 ar2840 This article is online at http arthritis-research.com content 11 6 136 2009 BioMed Central Ltd See related research by Abreu et al. http arthritis-research.com content 11 4 R121 Abstract The shared characteristics of rheumatoid arthritis RA and cancer particularly their unchecked growth and invasive behaviors have been apparent for some time. However the molecular mechanisms underlying these similarities are not clear. In a recent issue of Arthritis Research Therapy Abreu and colleagues link a well-studied oncogene Ras with expression of matrix metalloproteinase-3 MMP-3 in RA. Their study correlates expression of the Ras guanine nucleotide exchange factor RasGRF1 with MMP-3 expression in RA synovium. They elucidate a potential mechanism of regulation of MMP-3 expression in RA suggesting a potential target for RA treatment. In a recent issue of Arthritis Research Therapy Abreu and colleagues 1 demonstrate that the Ras guanine nucleotide exchange factor GEF RasGRF1 regulates production of matrix metalloproteinase-3 MMP-3 stromelysin in synovial cells taken from the joints of patients with rheumatoid arthritis RA . The data suggest that overexpression of RasGRF1 activates signal transduction pathways that target the MMP-3 gene thereby contributing to joint destruction in RA. In addition to measuring MMP-3 expression they measured levels of the interstitial collagenase MMP-1 and several other genes involved in RA. Interestingly production
