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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: How can we reduce the risk of serious infection for patients with systemic lupus erythematosus? | Available online http arthritis-research.eom content 11 5 129 Editorial How can we reduce the risk of serious infection for patients with systemic lupus erythematosus Diane L Kamen Division of Rheumatology Medical University of South Carolina 96 Jonathan Lucas Street Suite 912 Charleston South Carolina SC 29425-2229 USA Corresponding author Diane L Kamen kamend@musc.edu Published 28 October 2009 Arthritis Research Therapy 2009 11 129 doi 10.1186 ar2818 This article is online at http arthritis-research.com content 11 5 129 2009 BioMed Central Ltd See related research by Ruiz-Irastorza et al. http arthritis-research.com content 11 4 R109 Abstract Infection is responsible for approximately 25 of all deaths in patients with systemic lupus erythematosus SLE making it a leading cause of mortality among patients. Ruiz-Irastorza and colleagues in a recent issue of Arthritis Research Therapy report the clinical predictors of major infections found in a prospective study of patients with SLE. Similar patterns of infection and pathogens as reported in previous studies were seen what is striking however was the protective effect seen with anti-malarial use. Many infections in patients with SLE could be prevented with timely vaccinations reducing exposure to contagious contacts screening for latent infections minimizing exposure to corticosteroids targeted prophylaxis for high risk patients and unless contraindicated anti-malarial therapy as standard of care. In a recent issue of Arthritis Research Therapy Ruiz-Irastorza and colleagues 1 report the clinical predictors of major infections found in a prospective cohort of patients with systemic lupus erythematosus SLE from Spain. The 83 patients with at least one major infection were compared to 166 patients with no major infection history. Major infection is defined as disseminated affecting deep organs requiring hospital admission for treatment or causing death. Their report includes a number of methodological improvements over
