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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Expression of cartilage-derived morphogenetic protein in human intervertebral discs and its effect on matrix synthesis in degenerate human nucleus pulposus cells. | Available online http arthritis-research.eom content 11 5 R137 Research article Expression of cartilage-derived morphogenetic protein in human intervertebral discs and its effect on matrix synthesis in degenerate human nucleus pulposus cells Christine L Le Maitre1 2 Anthony J Freemont2 and Judith A Hoyland2 Biomedical Research Centre Biosciences Faculty of Health and Wellbeing Sheffield Hallam University City Campus Owen Building Howard Street Sheffield S1 1WB UK 2Tissue Injury and Repair Group School of Clinical and Laboratory Sciences Faculty of Medical and Human Sciences Stopford Building The University of Manchester Oxford Road Manchester M13 9PT UK Corresponding author Judith A Hoyland judith.hoyland@manchester.ac.uk Received 26 Mar 2009 Revisions requested 15 May 2009 Revisions received 30 Jul 2009 Accepted 15 Sep 2009 Published 15 Sep 2009 Arthritis Research Therapy 2009 11 R137 doi 10.11 86 ar2808 This article is online at http arthritis-research.com content 11 5 R137 2009 Le Maitre et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Loss of intervertebral disc IVD matrix and ultimately disc height as a result of degeneration has been implicated as a major cause of low back pain LBP . The use of anabolic growth factors as therapies to regenerate IVD matrix hence restoring disc height and thus reversing degenerative disc disease has been suggested. Cartilage-derived morphogenetic protein CDMP is a growth factor which stimulates proteoglycan production in chondrocyte-like cells and thus could be a useful growth factor for LBP therapies. However little is known about the expression of CDMP or its receptor in human IVD nor its effects on human disc cells. Methods Using .
