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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Regulatory T cells in systemic lupus erythematosus: past, present and future. | Available online http arthritis-research.eom content 10 6 227 Review Regulatory T cells in systemic lupus erythematosus past present and future David A Horwitz Division of Rheumatology and Immunology Department of Medicine University of Southern California Keck School of Medicine 2011 Zonal Avenue HMR 711 Los Angeles CA 90033 USA Corresponding author David A Horwitz dhorwitz@usc.edu Published 14 November 2008 This article is online at http arthritis-research.com content 10 6 227 2008 BioMed Central Ltd Arthritis Research Therapy 2008 10 227 doi 10.1186 ar2511 Abstract Regulatory suppressor T cells Tregs maintain immunologic homeostasis and prevent autoimmunity. In this article past studies and recent studies of Tregs in mouse models for lupus and of human systemic lupus erythematosus are reviewed concentrating on CD4 CD25 Foxp3 Tregs. These cells consist of thymus-derived natural Tregs and peripherally induced Tregs that are similar phenotypically and functionally. These Tregs are decreased in young lupus-prone mice but are present in normal numbers in mice with established disease. In humans most workers report CD4 Tregs are decreased in subjects with active systemic lupus erythematosus but the cells increase with treatment and clinical improvement. The role of immunogenic and tolerogenic dendritic cells in controlling Tregs is discussed along with new strategies to normalize Treg function in systemic lupus erythematosus. Introduction Systemic lupus erythematosus SLE is a disorder of immune regulation characterized by the breakdown of tolerance to self-nuclear cytoplasmic and cell surface molecules and by the production of autoantibodies to these elements. The result is generalized autoimmunity manifested by multisystem chronic inflammatory disease. Many T-cell and B-cell abnormalities have been described and these include defects in the regulatory suppressor T cells Tregs that normally prevent pathologic self-reactivity. In the present article we shall review the
