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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Developments in the scientific and clinical understanding of inflammatory myopathies. | Available online http arthritis-research.eom content 10 5 220 Review Developments in the scientific and clinical understanding of inflammatory myopathies Ingrid E Lundberg and Cecilia Grundtman Rheumatology Unit Department of Medicine Karolinska University Hospital - Solna Karolinska Institutet SE-171 76 Stockholm Sweden Corresponding author Ingrid E Lundberg ingrid.lundberg@ki.se Published 10 October 2008 This article is online at http arthritis-research.com content 10 5 220 2008 BioMed Central Ltd Arthritis Research Therapy 2008 10 220 doi 10.1186 ar2501 Abstract The idiopathic inflammatory myopathies are chronic autoimmune disorders sharing the clinical symptom of muscle weakness and in typical cases inflammatory cell infiltrates in muscle tissue. During the last decade novel information has accumulated supporting a role of both the innate and adaptive immune systems in myositis and suggesting that different molecular pathways predominate in different subsets of myositis. The type I interferon activity is one such novel pathway identified in some subsets of myositis. Furthermore nonimmunological pathways have been identified suggesting that factors other than direct T cell-mediated muscle fibre necrosis could have a role in the development of muscle weakness. Introduction The idiopathic inflammatory myopathies collectively called myositis constitute a heterogeneous group of chronic disorders sharing the predominating clinical symptom of muscle weakness and in classical cases histopathological signs of inflammation in muscle tissue. Immunohistochemical analyses of human muscle biopsies have characterised two major types of cellular infiltrates defined by localisation and cellular phenotypes a endomysial inflammatory infiltrates composed of mononuclear cells with an appreciable number of T cells typically surrounding muscle fibres without features indicating degeneration or necrosis and with a high prevalence of CD8 T cells but also CD4 T cells and the presence of