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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Nucleus pulposus cells as competent phagocytes to clear apoptotic cells: mission applicable or impossible? Authors’ response. | Available online http arthritis-research.eom content 11 3 406 Letter Nucleus pulposus cells as competent phagocytes to clear apoptotic cells mission applicable or impossible Authors response Philip Jones1 2 Lucy Gardner1 2 Janis Menage1 Gwyn T Williams2 and Sally Roberts1 2 Centre for Spinal Studies Robert Jones Agnes Hunt Orthopaedic District Hospital NHS Trust Oswestry Shropshire SY10 7AG UK institute of Science and Technology in Medicine Keele University Keele Staffordshire ST5 5BG UK Corresponding author Sally Roberts Sally.Roberts@rjah.nhs.uk Published 6 May 2009 Arthritis Research Therapy 2009 11 406 doi 10.1186 ar2672 This article is online at http arthritis-research.com content 11 3 406 2009 BioMed Central Ltd See related research by Jones et al. http arthritis-research.com content 10 4 R86 and related letter by Wang and Luo http arthritis-research.com content 11 3 405 We thank Dr Wang and Dr Luo for their interest in our paper demonstrating the ability of intervertebral disc cells to undergo phagocytosis 1 and we can certainly concur with some of the points they raise 2 . In fact we addressed the first point in the last paragraph of the Discussion stating that Although disc cells usually occur in isolation . disc cells do occur adjacent to each other in clusters of cells that are common in degenerate discs 1 . It is in this situation that we suggest our findings could have relevance in vivo in humans. We would suggest that the second point made by Wang and Luo has very little bearing on our study. In intact adult discs there is little evidence of T cells being present and therefore this comment is of limited relevance. Wang and Luo s third point is certainly true and pertinent to all cell culture studies - the results of which can only be interpreted bearing in mind all the limitations of making any deductions from in vitro studies to an in vivo situation. The objective of the study was to determine whether disc cells could undergo phagocytosis 1 a .
