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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: The role of hypoxia and HIF-dependent signalling events in rheumatoid arthritis. | Available online http arthritis-research.eom content 11 1 201 Review Hypoxia The role of hypoxia and HIF-dependent signalling events in rheumatoid arthritis Barbara Muz1 Moddasar N Khan1 2 Serafim Kiriakidis1 and Ewa M Paleolog1 3 Kennedy Institute of Rheumatology Charing Cross Campus Faculty of Medicine Imperial College Aspenlea Road London W6 8LH UK 2Renal Section Division of Medicine Hammersmith Campus Faculty of Medicine Imperial College Du Cane Road London W12 0NN UK 3Division of Surgery Oncology Reproductive Biology Anaesthetics Faculty of Medicine Imperial College Aspenlea Road London W6 8LH UK Corresponding author Ewa Paleolog e.paleolog@imperial.ac.uk Published 20 January 2009 This article is online at http arthritis-research.com content 11 1 201 2009 BioMed Central Ltd Arthritis Research Therapy 2009 11 201 doi 10.1186 ar2568 Abstract An adequate supply of oxygen and nutrients is essential for survival and metabolism of cells and consequentially for normal homeostasis. Alterations in tissue oxygen tension have been postulated to contribute to a number of pathologies including rheumatoid arthritis RA in which the characteristic synovial expansion is thought to outstrip the oxygen supply leading to areas of synovial hypoxia and hypoperfusion. Indeed the idea of a therapeutic modality aimed at starving tissue of blood vessels was born from the concept that blood vessel formation angiogenesis is central to efficient delivery of oxygen to cells and tissues and has underpinned the development of anti-angiogenic therapies for a range of cancers. An important and well characterized master regulator of the adaptive response to alterations in oxygen tension is hypoxia-inducible factor HIF which is exquisitely sensitive to changes in oxygen tension. Activation of the HIF transcription factor signalling cascade leads to extensive changes in gene expression which allow cells tissues and organisms to adapt to reduced oxygenation. One of the best characterized .
