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Since the discovery of hepatitis C virus (HCV) in 1989, there has been an explosion of research and information on the virus. This is evidenced by the more than 20 000 papers onHCV(as of December, 2000), as well as the numerous reviews in journals and edited books. The purpose of this book is to present an overview of the diVerent disciplines that have contributed to an understanding of the virus, its diseases, current and proposed treatments, and much more. Importantly, this book attempts to integrate the various disciplines to provide an overall picture of what has been accomplished in the Weld, and what major questions still remain | Hepatitis c Virus From Laboratory to Clinic Mark A. Feitelson Cambridge more information - www.cambridge.org 0521799597 This page intentionally left blank Hepatitis C Virus from Laboratory to Clinic Hepatitis C infects 170 million people worldwide and has been labeled the silent epidemic since it is asymptomatic for years after infection. This multidisciplinary overview covers basic concepts related to the discovery of the virus development of serological and nucleic acid tests to detect infection the structure of the virus genome generation of virus gene products and proposed replication scheme. It then goes on to introduce the epidemiology transmission pathogenesis of infection the development of hepatocellular carcinoma associated with chronic virus infection and current strategies for treatment. The book then discusses advances in cell culture systems animal models of infection and emerging treatments and vaccine development. Through its coverage of basic science clinical consequences and methods of research this integrated and accessible account will be of immense value to biomedical scientists and clinicians alike and a useful introduction for all those studying the virus and its effects. y Combines basic science clinical aspects and laboratory approaches to investigation y Extensively cross-referenced for easy access to concepts y An accessible introduction to a complex field. Mark A. Feitelson is currently Professor in the Department of Pathology Anatomy and Cell Biology Thomas Jefferson University Philadelphia. He has a secondary appointment in the Department of Microbiology and Immunology and is a member of the Kimmel Cancer Center at Thomas Jefferson University. In addition he is Head of the Molecular Diagnostics Laboratory in Microbiology for Thomas Jefferson University Hospital. Prior to his transfer to Jefferson Medical College Dr Feitelson trained with the Nobel laureate Dr Baruch S. Blumberg at the Fox Chase Cancer Center. Dr Feitelson has been .
