Đang chuẩn bị nút TẢI XUỐNG, xin hãy chờ
Tải xuống
Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài:ABT-869, a promising multi-targeted tyrosine kinase inhibitor: from bench to bedside | BioMed Central Journal of Hematology Oncology Open Access Review ABT-869 a promising multi-targeted tyrosine kinase inhibitor from bench to bedside Jianbiao Zhou1 2 Boon-Cher Goh2 3 Daniel H Albert4 and Chien- Shing Chen 1 5 Address Department of Medicine Yong Loo Lin School of Medicine National University of Singapore Singapore 2Cancer Science Institute of Singapore National University of Singapore Singapore 3Department of Hematology and Oncology National University Hospital Singapore 4Cancer Research Abbott Laboratories Abbott Park Illinois USA and 5School of Medicine Division of Hematology and Oncology Loma Linda University Loma Linda California USA Email Jianbiao Zhou - mdczjb@nus.edu.sg Boon-Cher Goh - phcgbc@nus.edu.sg Daniel H Albert - Daniel.H.Albert@abbott.com Chien-Shing Chen - mdcccs@nus.edu.sg Corresponding author Published 30 July 2009 Received 4 June 2009 Journal of Hematology Oncology 2009 2 33 doi 10.1186 1756-8722-2-33 Accepted 30 July 2009 This article is available from http www.jhoonline.Org content 2 1 33 2009 Zhou et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract__ Tyrosine Kinase Inhibitors TKI have significantly changed the landscape of current cancer therapy. Understanding of mechanisms of aberrant TK signaling and strategies to inhibit TKs in cancer further promote the development of novel agents. ABT-869 a novel ATP-competitive receptor tyrosine kinase inhibitor is a potent inhibitor of members of the vascular endothelial growth factor VEGF and platelet derived growth factor PDGF receptor families. ABT-869 showed potent antiproliferative and apoptotic properties in vitro and in animal cancer xenograft .
