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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Dysregulation of CXCL9 and reduced tumor growth in Egr-1 deficient mice | BioMed Central Journal of Hematology Oncology Research Dysregulation of CXCL9 and reduced tumor growth in Egr-1 deficient mice Giuseppe Caso1 Catherine Barry2 and Gerald Patejunas 1 Open Access Address Department of Surgery Stony Brook University Stony Brook NY USA and 2Abbott Laboratories Des Plaines IL USA Email Giuseppe Caso - giuseppe.caso@stonybrook.edu Catherine Barry - catherine.barry@abbott.com Gerald Patejunas - gpatejunas@metacrawler.com Corresponding author Published 7 February 2009 Received 23 October 2008 Journal of Hematology Oncology 2009 2 7 doi 10.1186 1756-8722-2-7 Accepted 7 February 2009 This article is available from http www.jhoonline.Org content 2 1 7 2009 Caso et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract_ Background Early growth response-1 Egr-I is an immediate-early transcription factor inducible in the vasculature in response to injury shear stress and other stimuli. Mice lacking Egr- 1 have a profound deficit in the ability to recover from femoral artery ligation suggesting a role in neovascularization. Previous studies have shown that manipulating Egr- 1 expression can have either positive or negative effects on tumor growth. We hypothesized that Egr-1 knockout mice might exhibit reduced tumor growth possibly due to a reduced capacity to respond to angiogenic signals from a growing tumor. Results We injected 106 Lewis lung carcinoma LLC1 cells subcutaneously in the flank of wild type and Egr-1 knockout mice. The average mass of tumors from wild type mice at 12 days after implantation was 413 - 128 mg while those from Egr-1- - mice was 219 - 81 mg p 0.001 mean - SD . However sectioning the tumors and .
