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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Allogeneic hematopoietic stem cell transplantation for acute leukemia with Gilbert’s syndrome. | Yu et al. Journal of Hematology Oncology 2011 4 9 http www.jhoonline.Org content 4 1 9 JOURNAL OF HEMATOLOGY ONCOLOGY LETTER TO THE EDITOR Open Access Allogeneic hematopoietic stem cell transplantation for acute leukemia with Gilbert s syndrome Guo-Pan Yu Qian-Li Jiang Zhi-Ping Fan Jie Zhao Qi Wei Jing Sun Fan-Yi Meng Qi-Fa Liu Abstract Acute leukemia with coexisting Gilbert s syndrome treated by allogeneic hematopoietic stem cell transplantation allo-HSCT is rarely reported. Here we described a case whose transaminase levels were almost normal although transient hyperbilirubinemia repeatedly happened during chemotherapy. To the editor We have seen a 52-year-old man with AML-FAB M2a subtype who had no history of viral hepatitis. He had history of mild indirect hyperbilirubinemia with normal transaminase levels after he took paracetamols in the past two years and the same phenomenon occurred to his siblings children and nephews. He received three cycles of chemotherapy containing daunorubicin idaru-bicin pirarubicin cytarabine and obtained CR in the first cycle. His bilirubin level was normal before chemotherapy however mild non-hemolytic indirect hyperbilirubinemia happened to him during each cycle of chemotherapy Figure 1 . Neither autoimmune antibodies nor serology of viral hepatitis were positive. CT scan revealed that liver parenchyma gallbladder and bile duct were all normal. The histopathology of a liver biopsy showed mild chronic hepatitis and hepatocellular cholestasis. The expression of UGT1A1 gene was found to decrease by 20 . The diagnosis of Gilbert s syndrome was confirmed. After 3 cycles of chemotherapy the patient received transplantation from his HLA-identical sibling sister who was also diagnosed to have GS. The conditioning regimen included fludarabine and busulfan. Hematopoietic engraftment was observed on day 11. In the absence of GVHD the levels of transaminase and bilirubin were almost normal within 100 days post-transplantation Figure 1 . The