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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: " Is translational research compatible with preclinical publication strategies?. | Radiation Oncology BioMed Central Commentary Open Access Is translational research compatible with preclinical publication strategies Stig Linder and Maria C Shoshan Address Cancer Center Karolinska Department of Oncology and Pathology Karolinska Institute and Hospital S-171 76 Stockholm Sweden Email Stig Linder - Stig.Linder@cck.ki.se Maria C Shoshan - Mimmi.Shoshan@onkpat.ki.se Corresponding author Published 24 March 2006 Received 06 December 2005 Accepted 24 March 2006 Radiation Oncology2006 1 4 doi 10.1186 1748-717X-1 -4 This article is available from http www.ro-journal.com content 1 1 4 2006Linder and Shoshan licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.Org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract The term translational research is used to describe the transfer of basic biological knowledge into practical medicine a process necessary for motivation of public spending. In the area of cancer therapeutics it is becoming increasingly evident that results obtained in vitro and in animal models are difficult to translate into clinical medicine. We here argue that a number of factors contribute to making the translation process inefficient. These factors include the use of sensitive cell lines and fast growing experimental tumors as targets for novel therapies and the use of unrealistic drug concentrations and radiation doses. We also argue that aggressive interpretation of data successful in hypothesis-building biological research does not form a solid base for development of clinically useful treatment modalities. We question whether clean results obtained in simplified models expected for publication in high-impact journals represent solid foundations for improved treatment of patients. Open-access journals such as Radiation Oncology have a large mission
