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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Expression and regulation of neurotrophins in the nondegenerate and degenerate human intervertebral disc. | Available online http arthritis-research.eom content 10 4 R99 Research article Expression and regulation of neurotrophins in the nondegenerate and degenerate human intervertebral disc Devina Purmessur Anthony J Freemont and Judith A Hoyland Tissue Injury and Repair School of Clinical and Laboratory Sciences Faculty of Medical and Human Sciences Stopford Building Oxford Road The University of Manchester Manchester M13 9PT UK Corresponding author Judith A Hoyland judith.a.hoyland@manchester.ac.uk Received 10 Jun 2008 Revisions requested 11 Jul 2008 Revisions received 23 Jul 2008 Accepted 27 Aug 2008 Published 27 Aug 2008 Arthritis Research Therapy 2008 10 R99 doi 10.1186 ar2487 This article is online at http arthritis-research.com content 10 4 R99 2008 Purmessur et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction The neurotrophins nerve growth factor NGF and brain-derived neurotrophic factor BDNF have been identified in the human intervertebral disc IVD and have been implicated in the mechanisms associated with nerve ingrowth and nociception in degeneration of the IVD. The aim of the current study was to investigate an association between neurotrophin expression in the IVD and the severity of disc degeneration including the effect of disc-related proinflammatory cytokines on neurotrophin and neuropeptide expression in cells derived from the human IVD. Methods Immunohistochemical analysis was performed to examine the expression of NGF BDNF and their high-affinity receptors Trk-A and Trk-B in human IVD samples divided into three categories non-degenerate moderate degeneration and severe degeneration. In order to study the effect of disc-related cytokines on neurotrophin neuropeptide gene .