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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Systemic TNF blockade does not modulate synovial expression of the pro-inflammatory mediator HMGB1 in rheumatoid arthritis patients – a prospective clinical study. | Available online http arthritis-research.eom content 10 2 R33 Research article Systemic TNF blockade does not modulate synovial expression of the pro-inflammatory mediator HMGB1 in rheumatoid arthritis patients - a prospective clinical study Erik Sundberg1 2 Cecilia Grundtman2 Erik af Klint2 Johan Lindberg3 Sofia Ernestam2 Ann-Kristin Ulfgren2 Helena Erlandsson Harris2 and Ulf Andersson1 Department of Woman and Child Health Pediatric Rheumatology Research Unit Karolinska Institutet Karolinska University Hospital Stockholm Sweden department of Medicine Rheumatology Unit Karolinska Institutet Karolinska University Hospital Stockholm Sweden department of Biotechnology AlbaNova University Center Royal Institute of Technology Stockholm Sweden Corresponding author Erik Sundberg erik.sundberg@ki.se Received 21 Nov 2007 Revisions requested 23 Jan 2008 Revisions received 26 Feb 2008 Accepted 17 Mar 2008 Published 17 Mar 2008 Arthritis Research Therapy 2008 10 R33 doi 10.1186 ar2387 This article is online at http arthritis-research.com content 10 2 R33 2008 Sundberg et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction High-mobility group box chromosomal protein 1 HMGB1 has recently been identified as an endogenous mediator of arthritis. TNF and IL-1P pivotal cytokines in arthritis pathogenesis both have the ability to induce the release of HMGB1 from myeloid and dendritic cells. It was therefore decided to investigate whether treatment based on TNF blockade in rheumatoid arthritis RA affects the expression of synovial HMGB1. Methods Repeated arthroscopy-guided sampling of synovial tissue was performed in nine patients with RA before and nine weeks after initiation of anti-TNF mAb infliximab .
