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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: The relationship between cancer and rheumatoid arthritis: still a large research agenda. | Available online http arthritis-research.eom content 10 3 109 Editorial The relationship between cancer and rheumatoid arthritis still a large research agenda Thorvardur Love and Daniel H Solomon Division of Rheumatology Immunology and Allergy Brigham and Women s Hospital Harvard Medical School Francis Street Boston MA 02115 USA Corresponding author Daniel H Solomon dsolomon@partners.org Published 14 May 2008 Arthritis Research Therapy 2008 10 109 doi 10.1186 ar2417 This article is online at http arthritis-research.com content 10 3 109 2008 BioMed Central Ltd See related research by Smitten et al. http arthritis-research.com content 10 2 R45 Abstract The association between rheumatoid arthritis RA and malignancies has received increased attention in recent years. Reports suggesting that tumor necrosis factor blockers might elevate the risk of malignancy in RA patients have prompted researchers to look at the incidence of malignancies in all RA patients. In a recent issue of Arthritis Research Therapy Smitten and colleagues suggest that previous reports of a standardized incidence ratio close to one for malignancies in RA may reflect an increased risk for some site-specific malignancies and a reduced risk for others. Here we discuss these findings and suggest what issues could be addressed in future studies. In a recent issue of Arthritis Research Therapy Smitten and colleagues 1 reported the results of a meta-analysis of studies looking at the relative risk of malignancies in rheumatoid arthritis RA patients compared to the general population as expressed by a standardized incidence ratio SIR . While their finding of a SIR of 1.05 for all malignancies in this group supports previous studies they report SIRs for lymphoma of 2.08 and lung cancer of 1.63 and decreased relative risks for colorectal cancer of 0.77 and breast cancer of 0.84. These results suggest that the previously reported SIR close to 1 for all malignancies in RA patients 2 may be explained in part by
