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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: IL-23 induces human osteoclastogenesis via IL-17 in vitro, and anti-IL-23 antibody attenuates collagen-induced arthritis in rats. | Available online http arthritis-research.eom content 9 5 R96 Research article IL-23 induces human osteoclastogenesis via IL-17 in vitro and anti-IL-23 antibody attenuates collagen-induced arthritis in rats Toru Yago Yuki Nanke Manabu Kawamoto Takefumi Furuya Tsuyoshi Kobashigawa Naoyuki Kamatani and Shigeru Kotake Institute of Rheumatology Tokyo Women s Medical University 10-22 Kawada-cho Shinjuku-ku Tokyo 162-0054 Japan Corresponding author Toru Yago toruyago@ior.twmu.ac.jp Received 4 Mar 2007 Revisions requested 13 Apr 2007 Revisions received 12 Sep 2007 Accepted 23 Sep 2007 Published 23 Sep 2007 Arthritis Research Therapy 2007 9 R96 doi 10.1186 ar2297 This article is online at http arthritis-research.com content 9 5 R96 2007 Yago et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract This study demonstrates that IL-23 stimulates the differentiation of human osteoclasts from peripheral blood mononuclear cells PBMC . Furthermore in vivo blockade of endogenous IL-23 activity by treatment with anti-IL-23 antibody attenuates collagen-induced arthritis in rats by preventing both inflammation and bone destruction. IL-23 induced human osteoclastogenesis in cultures of PBMC in the absence of osteoblasts or exogenous soluble-receptor activator of NF-kappaB ligand RANKL . This IL-23-induced osteoclastogenesis was inhibited by osteoprotegerin anti-IL-17 antibody and etanercept suggesting that RANKL IL-17 and TNF-alpha are involved. In addition we found the ratio of production levels of IL-17 to those of IFN-gamma from activated human T cells was elevated at 1 to 10 ng ml IL-23. The inductive effect of IL-17 and the inhibitory effect of IFN-gamma on osteoclastogenesis indicate that the balance of these two .
