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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: " Peripheral blood complete remission after splenic irradiation in Mantle-Cell Lymphoma with 11q22-23 deletion and ATM inactivation. | Radiation Oncology BioMed Central Open Access Short report Peripheral blood complete remission after splenic irradiation in Mantle-Cell Lymphoma with 11q22-23 deletion and ATM inactivation Andrea Riccardo Filippi 1 Pierfrancesco Franco1 Marco Galliano2 and Umberto Ricardi1 Address 1Radiation Oncology University of Torino Ospedale S. Giovanni Battista Torino Italy and 2Medical Oncology Ospedale Alba-Bra-ASL 18 Alba-Bra Italy Email Andrea Riccardo Filippi - andrea.filippi@unito.it Pierfrancesco Franco - pier4377@yahoo.it Marco Galliano - mgalliano@asl18.it Umberto Ricardi - umberto.ricardi@unito.it Corresponding author Published 06 September 2006 Received 29 June 2006 Accepted 06 September 2006 Radiation Oncology 2006 1 35 doi 10.1186 1748-717X-1-35 This article is available from http www.ro-journal.cOm content 1 1 35 2006 Filippi et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Mantle Cell Lymphoma MCL is a well-known histological and clinical subtype of B-cell nonHodgkin s Lymphomas. It is usually characterized by an aggressive disease course presenting with advanced stage disease at diagnosis and with low response rates to therapy. However few cases of indolent course MCL have been described. We herein report a case of MCL with splenomegaly and peripheral blood involvement as main clinical features. The patient underwent moderate dose splenic radiation therapy and achieved spleen downsizing and peripheral blood complete remission. Splenic irradiation has been extensively used in the past as palliative treatment in several lymphoproliferative disorders and a systemic effect and sometimes peripheral blood complete remissions have been observed. Mainly advocated mechanisms responsible for this phenomenon are .
