Đang chuẩn bị liên kết để tải về tài liệu:
Báo cáo y học: " Patients with early rheumatoid arthritis exhibit elevated autoantibody titers against mildly oxidized low-density lipoprotein and exhibit decreased activity of the lipoprotein-associated phospholipase A2"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Patients with early rheumatoid arthritis exhibit elevated autoantibody titers against mildly oxidized low-density lipoprotein and exhibit decreased activity of the lipoprotein-associated phospholipase A2. | Available online http arthritis-research.eom content 9 1 R19 Research article Patients with early rheumatoid arthritis exhibit elevated autoantibody titers against mildly oxidized low-density lipoprotein and exhibit decreased activity of the lipoprotein-associated phospholipase A2 Evangelia S Lourida1 Athanasios N Georgiadis2 Eleni C Papavasiliou1 Athanasios I Papathanasiou2 Alexandros A Drosos2 and Alexandros D Tselepis1 Department of Chemistry Laboratory of Biochemistry University of loannina 45110 loannina Greece department of Internal Medicine Medical School University of loannina 45110 loannina Greece Corresponding author Alexandros D Tselepis atselep@uoi.gr Received 20 Oct 2006 Revisions requested 4 Dec 2006 Revisions received 22 Jan 2007 Accepted 27 Feb 2007 Published 27 Feb 2007 Arthritis Research Therapy 2007 9 R19 doi 10.1186 ar2129 This article is online at http arthritis-research.com content 9 1 R19 2007 Lourida et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Rheumatoid arthritis is a chronic inflammatory disease associated with an excess of cardiovascular morbidity and mortality due to accelerated atherosclerosis. Oxidized low-density lipoprotein oxLDL the antibodies against oxLDL and the lipoprotein-associated phospholipase A2 Lp-PLA2 may play important roles in inflammation and atherosclerosis. We investigated the plasma levels of oxLDL and Lp-PLA2 activity as well as the autoantibody titers against mildly oxLDL in patients with early rheumatoid arthritis ERA . The long-term effects of immunointervention on these parameters in patients with active disease were also determined. Fifty-eight ERA patients who met the American College of Rheumatology criteria were included in the study.