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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: Clinical Analysis of stereotactic body radiation therapy using extracranial gamma knife for patients with mainly bulky inoperable early stage non-small cell lung carcinoma. | Wu et al. Radiation Oncology 2011 6 84 http www.ro-journal.eom content 6 1 84 RADIATION ONCOLOGY RESEARCH Open Access Clinical Analysis of stereotactic body radiation therapy using extracranial gamma knife for patients with mainly bulky inoperable early stage non-small cell lung carcinoma Dajun Wu1 2t Hong Zhu1t Hanjun Tang2 Changlin Li2 and Feng Xu1 Abstract Purpose To evaluate the clinical efficacy and toxicity of stereotactic body radiation therapy SBRT using extracranial gamma knife in patients with mainly bulky inoperable early stage non-small cell lung carcinoma NSCLC . Materials and methods A total of 43 medically inoperable patients with mainly bulky Stage I II NSCLC received SBRT using gamma knife were reviewed. The fraction dose and the total dose were determined by the radiation oncologist according to patients general status tumor location tumor size and the relationship between tumor and nearby organ at risk OAR . The total dose of 34 47.5 Gy was prescribed in 4 12 fractions 3.5 10 Gy per fraction one fraction per day or every other day. The therapeutic efficacy and toxicity were evaluated. Results The median follow-up was 22 months range 3-102 months . The local tumor response rate was 95.35 with CR 18.60 8 43 and PR 76.74 33 43 respectively. The local control rates at 1 2 3 5 years were 77.54 53.02 39.77 and 15.46 respectively while the 1- and 2-year local control rates were 75 and 60 for tumor 3 cm 84 and 71 for tumor sized 3 5 cm 55 and 14.6 for tumor sized 5 7 cm and 45 21 in those with tumor size of 7 cm. The overall survival rate at 1 2 3 5 years were 92.04 78.04 62.76 42.61 respectively. The toxicity of stereotactic radiation therapy was grade 1-2. Clinical stages were significantly important factor in local control of lung tumors P 0.000 . Both clinical stages P 0.015 and chemotherapy P 0.042 were significantly important factors in overall survival of lung tumors. Conclusion SBRT is an effective and safe therapy for medically inoperable .
