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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: Postmastectomy irradiation in breast in breast cancer patients with T1-2 and 1-3 positive axillary lymph nodes: Is there a role for radiation therapy? | Cosar et al. Radiation Oncology 2011 6 28 http www.ro-journal.eom content 6 1 28 RADIATION ONCOLOGY RESEARCH Open Access Postmastectomy irradiation in breast in breast cancer patients with T1-2 and 1-3 positive axillary lymph nodes Is there a role for radiation therapy o - 1 1 2 1 1 3 4 Rusen Cosar Cem Uzal Fusun Tokatli Bengu Denizli Mert Saynak Nesrin Turan Sernaz Uzunoglu 15 11 1 1 Alaattin Ozen Atakan Sezer Kamuran Ibis Burcu Uregen Vuslat Yurut-Caloglu and Zafer Kocak Abstract Background We aimed to evaluate retrospectively the correlation of loco-regional relapse LRR rate distant metastasis DM rate disease free survival DFS and overall survival OS in a group of breast cancer BC patients who are at intermediate risk for LRR T1-2 tumor and 1-3 positive axillary nodes treated with or without postmastectomy radiotherapy PMRT following modified radical mastectomy MRM . Methods Ninety patients with T1-T2 tumor and 1-3 positive nodes who had undergone MRM received adjuvant systemic therapy with n 66 or without n 24 PMRT. Patient-related characteristics age menopausal status pathological stage tumor size tumor location histology estrogen progesterone receptor status histological grade nuclear grade extracapsular extension lymphatic vascular and perineural invasion and ratio of involved nodes dissected nodes and treatment-related factors PMRT chemotherapy and hormonal therapy were evaluated in terms of LRR and DM rate. The 5-year Kaplan-Meier DFS and OS rates were analysed. Results Differences between RT and no-RT groups were statistically significant for all comparisons in favor of RT group except OS LRR rate 3 vs 17 p 0.038 DM rate 12 vs 42 p 0.004 5 year DFS 82.4 vs 52.4 p 0.034 5 year OS 90 2 vs 61 9 p 0.087 . In multivariate analysis DM and lymphatic invasion were independent poor prognostic factors for OS. Conclusion PMRT for T1-2 N1-3 positive BC patients has to be reconsidered according to the prognostic factors and the decision has to be made individually .
